Wladis EJ et al. found that the expression of p38 and extracellular signal-regulated kinase in the eyelid skin tissue of patients with ocular rosacea was higher than that in the eyelid skin tissue of healthy people.[22] Yamasaki et al[6] and others found that LL37 can promote rosacea skin inflammation, whereas the inhibition of p38 can selectively inhibit the LL37-induced keratinocyte synthesis of IL-36ɣ.[23] ASK1 is a member of the mitogen-activated protein kinase kinase (MAP3K) family. Here, MAP3K5 is linked to rosacea.