DOCK8 also plays a critical role in brain development and cognitive function, which are associated with mental or behavioral disorders.[18] Heterozygous disruption of DOCK8 due to chromosomal deletion or a translocation breakpoint is related to autosomal dominant mental retardation 2 (OMIM 614113).[26] The effects of DOCK8 duplication have not been clearly identified. Here, DOCK8 is linked to intellectual disability, autosomal dominant 2.