Nevertheless, null association with AIS was found in the review of both locus ESR1 rs9340799 and ESR2 rs1256120.[12,13] In addition, investigation of insulin-like growth factor gene at locus IGF1 rs5742612 yielded no correlation.[14] However, positive result was suggested in ladybird homeobox gene at locus LBX1 rs11190870, which was confirmed by 3 reviews published in different years.[15–17]. The gene discussed is ESR1; the disease is androgen insensitivity syndrome.