TPH1 and androgen insensitivity syndrome: In 2008, Hai Wang was the first author who investigated the association of TPH1 rs10488682 with AIS and got positive results.[21] In 2011, Xu found positive results that TPH1 gene could significantly influence the effect of brace treatment in a case-only study.[26] Over the past decade, many researchers from different countries have studied this gene locus from many perspectives including predisposition, progression, and treatment prognosis.[20,26–28] However, they got controversial conclusions.