PCLAF and dengue disease: We have previously shown that many inflammatory lipid mediators such as platelet activating factor (PAF) and secretory phospholipase A2 levels were higher in patients with DHF, and that endothelial dysfunction induced by dengue sera was inhibited by PAF-R blockers, in vitro, which also showed a tend towards a reduction in vascular leakage in patients with acute dengue [3, 9, 13].