Since HD patients have markedly higher serum levels of NT-proBNP [31] and biomarker levels of NT-proBNP are one of the three diagnostic pillars in the HFA-PEFF score, the use of predefined NT-proBNP cut-off values might be another source of inaccuracy regarding the observed frequency of HFpEF. The gene discussed is NPPB; the disease is Huntington disease.