CD3+/HLA-DR+ [48], CD3+/CD4+ [48], CD146+ [19], CD66b+ [19], CD31+ [19, 23], CD41+ [37], CD42a [41], CD61+ [34, 41, 51, 54], and CD45+ [29] plasmatic EVs were found increased in RA when compared with HC. This evidence concerns the gene CD4 and rheumatoid arthritis.