RA fibroblast-like synoviocytes (FLS) induced a decrease in GM-CSF [55] and an increase in MCP-1 [55], sICAM-1 [55], VEGF [55], RANTES [55], BAFF [42], IL-6 [42, 55], and IL-8 [42, 55] after stimulation with SF EVs. This evidence concerns the gene CCL5 and rheumatoid arthritis.