eHSP90α translocation in the plasma membrane of different cancer cells and its subsequent release in the medium relies on different stimulus-activated cascades as the hypoxia-inducible factor (HIF) 1α and the epidermal growth factor (EGF)-induced phospholipase (PLC) γ1/protein kinase C (PKC) γ signalling [49]. The gene discussed is EGF; the disease is cancer.