In colorectal cancer (CRC) cells, eHSP90α through LRP1, increases the levels of phosphorylated IκB kinase (IKK) α/β and NF-κB and induces the expression of TCF12, a class I member of the helix-loop-helix protein family preferentially overexpressed in CRC patients with cancer metastasis. The gene discussed is TCF12; the disease is colorectal carcinoma.