The genes encoding PINK1 and Parkin are strongly implicated as mediators of familial and sporadic Parkinson’s disease [41], and the first studies showing the interaction between these proteins in vivo identified a role of Parkin in restoring mitochondrial morphology and function downstream of PINK1 in mutant models of Drosophila melanogaster [42–44]. Here, PRKN is linked to Parkinson disease.