CDKN2A and thyroid gland undifferentiated (anaplastic) carcinoma: Other tumor suppressor genes, such as p16(INK4A), TSHR, MGMT, DAPK, ESR1, ESR2, RARbeta, PTEN, CD26, SLC5A8, and UCHL1, are frequently methylated in anaplastic thyroid carcinomas as compared with well-differentiated carcinomas [45].