[78] demonstrated that synergy existed between both doxorubicin and Dp44mT in TNBC cell line (MDA-MB231) which is dependent on Pgp expression level and lysosomal permeability as Dp44mT helps to release doxorubicin from its entrapment within lysosome and reach the nucleus (its target) resulting in potent inhibition of cancer cell proliferation. The gene discussed is PGP; the disease is cancer.