TNFRSF1A and early-onset autosomal dominant Alzheimer disease: It has been demonstrated that TNFR1 signalling can modulate synaptic strength via exocytosis of AMPA receptors (Beattie et al., 2002; Stellwagen et al., 2005), and endocytosis of GABA receptors (Stellwagen et al., 2005), which may point to overlapping pathways involved in trafficking and exocytosis of protein aggregates in already vulnerable Alzheimer’s disease neurons in this case.