SARS-CoV-2 viral proteins might target several innate immune signaling proteins from pathways including the interferon (IFN) pathway, NF-κB pathway, and JAK/STAT signaling pathway [15, 41] that play crucial roles in excessive inflammation and immunopathology against virus infection, causing increased inflammatory cytokines/chemokines levels. This evidence concerns the gene SOAT1 and viral infectious disease.