Among the universal DEGs, 4 upregulated genes (<i>BGN</i>, <i>E2F3</i>, <i>PLAU</i>, and <i>SPP1</i>) and 1 downregulated gene (<i>UBL3</i>) were found to be cancer genes already documented in the COSMIC or F-Census databases. This evidence concerns the gene E2F3 and cancer.