SGK1 and colonic neoplasm: Towhid et al. (58) reported that pharmacological inhibition of SGK1 with EMD638683 (50 μM) synergized with low doses of radiation (3 GY) caused mitochondrial depolarization and late apoptosis (necro-apoptosis) in a colon carcinoma (CaCo-2) cell line, with a relative increase in caspase-3, indicating that EMD638683 promotes radiation-induced suicidal death of colon tumor cells.