Following chemical carcinogenesis, SGK1 knockout mice [sgk1(-/-)] mice developed significantly fewer colonic tumors than wild-type littermates [sgk1(+/+)], suggesting that SGK1 deficiency counteracts the development of colonic tumors, an effect due at least in part to upregulation of FOXO3a and BIM (47). The gene discussed is FOXO3; the disease is colonic neoplasm.