Following chemical carcinogenesis, SGK1 knockout mice [sgk1(-/-)] mice developed significantly fewer colonic tumors than wild-type littermates [sgk1(+/+)], suggesting that SGK1 deficiency counteracts the development of colonic tumors, an effect due at least in part to upregulation of FOXO3a and BIM (47). This evidence concerns the gene SGK1 and colonic neoplasm.