According to several reports (15, 55, 108, 109), SGK1 can modulate the function of immune cells, such as T helper (TH) cells, regulatory T cells (Tregs), and tumor-associated macrophages (TAMs), and plays an important role in the tumor microenvironment through crosstalk with cytokine signaling pathways (39, 110) and chemokine signaling pathways (111), as shown in Figure 4. This evidence concerns the gene SGK1 and neoplasm.