Using microarray and RNA-Seq-based gene expression profiling and ChIP-Seq analyses of breast cancer cells, Godbole et al. (130) observed that SGK1 and the tumor metastasis-suppressor gene NDRG1 are upregulated and that the microRNAs miR-29a and miR-101-1 targeting the 3’-UTR of SGK1 are downregulated in response to progesterone. Here, SGK1 is linked to breast carcinoma.