A growing number of investigations indicate that SGK1 has critical roles in tumorigenesis (47), cancer cell proliferation and apoptosis (48, 49), cancer cell invasion (50) and migration (51), cancer cell autophagy (19, 20, 30), cancer metabolism (52, 53), therapeutic resistance (6, 54), and the tumor microenvironment (39, 55). This evidence concerns the gene SGK1 and cancer.