A similar observation was made in adrenocortical carcinoma patients, Ronchi et al. (23) showed that low SGK1 protein levels were associated with poor overall survival in patients with adrenocortical carcinoma (P < 0.005; hazard ratio = 2.0; 95% confidence interval = 1.24–3.24), independent of tumor stage and glucocorticoid secretion. The gene discussed is SGK1; the disease is adrenal cortex carcinoma.