Cues in the tumor microenvironment (TME) have been informative in understanding the tumor-immune contexture.<h4>Methods</h4>In this preliminary study, the NanoString GeoMxTM Digital Spatial Profiling (DSP) technology was used to determine the immune marker and compartment specific measurements in a cohort of HNSCC tumors from patients receiving ICI therapy.<h4>Results</h4>Our data revealed that markers involved with immune cell infiltration (CD8 T-cells) were not predictive of outcome to ICI therapy. Here, CD8A is linked to neoplasm.