In addition, the expression level of E-cadherin was up-regulated and expressions of Vimentin, MMP-2, MMP-9, Slug and Snail were reduced in the xenografts in the KIF3B-shRNA group compared with the control group by IHC staining (Figure 8F), which were consistent with the results in breast cancer cell lines. This evidence concerns the gene MMP2 and breast carcinoma.