In addition, the expression level of E-cadherin was up-regulated and expressions of Vimentin, MMP-2, MMP-9, Slug and Snail were reduced in the xenografts in the KIF3B-shRNA group compared with the control group by IHC staining (Figure 8F), which were consistent with the results in breast cancer cell lines. The gene discussed is MMP9; the disease is breast cancer.