In this study, in order to reveal the possible regulatory network in metastatic ccRCC, we constructed a DE-miRNAs-DEGs regulatory network, in which, SFTPB-miR-328, SFTPB-miR-502, SFTPB-miR-504, and NKX2-1-miR-504 axes may play an important role in the occurrence and metastasis of ccRCC. This evidence concerns the gene SFTPB and nonpapillary renal cell carcinoma.