As depicted in Figures 5A–K, the increased expression of ten hub genes (FBLN1, THBS2, SCGB1A1, NKX2-1, COL11A1, DCN, LUM, COL1A1, COL6A3, and SFTPC) indicated poor prognosis in 530 patients with ccRCC (all P < 0.01). This evidence concerns the gene COL6A3 and nonpapillary renal cell carcinoma.