Our integrated bioinformatics analysis demonstrated a significant up-regulation of COL11A1, COL1A1, and COL6A3 in metastatic ccRCC tissues, suggesting a proto-oncogene effect of COL11A1, COL1A1, and COL6A3 in ccRCC metastasis. This evidence concerns the gene COL1A1 and nonpapillary renal cell carcinoma.