In recent years, studies have reported that plasma membrane vacuolar ATPase (V-ATPase) (22), Syndecan 1 (SDC1) (23), mTORC1/mTORC2 (24), and epidermal growth factor receptor (EGFR) pathways (25) are closely associated with the molecular mechanism of macropinocytosis in tumor cells. This evidence concerns the gene EGFR and neoplasm.