Besides, public data showed a positive correlation between the level of TDO2 and that of AhR in malignant tumors, including colon (Spearman r = 0.33, P = 3.2e-08) and rectum adenocarcinoma (Spearman r = 0.32, P = 0.0019), thymoma (Spearman r = 0.51, P = 3.4e-09), testicular Germ Cell Tumors (Spearman r = 0.53, P = 4.4e-11), and Uveal melanoma (UM) (Spearman r = 0.50, P = 2.2e-06) (Supplementary Figure 1C). Here, AHR is linked to rectum adenocarcinoma.