NPPB and ocular melanoma: The study's primary endpoint was the maximum concentration of OM at weeks 2 and 12 visits and the trough concentration at weeks 2, 8, 12, 16, and 20 visits. The study's secondary endpoints were changes from baseline in left ventricular end-systolic, and end-diastolic diameters, stroke volume, heart rate, systolic ejection time, and concentration of NT-proBNP in plasma at week 20.