Recently, a randomized, placebo-controlled clinical trial [71] that evaluated the potential impacts of saffron aqueous extract (SAE) and crocin on some atherosclerosis-related gene expression and serum levels of Ox-LDL and monocyte chemoattractant protein 1 (MCP-1) in patients with coronary artery disease (CAD). This evidence concerns the gene CCL2 and atherosclerosis.