Administration of PLE or Res increased the mRNA and protein levels of GSTM3 in LECs, implying that PLE or Res display an anti-ARC activity by GSTM3 to prevent the age-related cataract by protecting the lens from oxidative stress, and an increased mRNA and expression level of GSTM3 are observed in the LECs of selenite-induced age-related cataract treated with PLE or Res. The gene discussed is GSTM3; the disease is Age-related cataract.