Thus, our study was the first to prove the association of lower NLR with better PFS (HR = 1.67, 95% CI = (1.16–2.39), and P value = 0.005) and OS (HR = 1.66, 95% CI = (1.08–2.55), and P value = 0.02) in NSCLC patients treated with EGFR-TKIs. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.