SP-A and SP-D play dual roles in HIV infection and pre-incubation with HIV both neutralizes the virus to prevent infection of a cluster of differentiation (CD)4+ T cell line (PM1 cells), as well as enhance infection of immature monocyte-derived dendritic cells (IMDDCs) and subsequent transfer to T cells (50, 51). The gene discussed is SFTPA2; the disease is HIV infectious disease.