found that PKM2 activator TEPP-46 attenuates β-aminopropionitrile fumarate (BAPN)-induced mouse model of thoracic aortic aneurysm and dissection (TAAD) by inhibiting NLRP3 inflammasome-mediated IL-1β secretion. The gene discussed is NLRP3; the disease is thoracic aortic aneurysm.