found that PKM2 activator TEPP-46 attenuates β-aminopropionitrile fumarate (BAPN)-induced mouse model of thoracic aortic aneurysm and dissection (TAAD) by inhibiting NLRP3 inflammasome-mediated IL-1β secretion. The gene discussed is PKM; the disease is Rare disease with thoracic aortic aneurysm and aortic dissection.