For example, in MDS donor centromeric KIR haplotype B motifs appeared to be disadvantageous (HR, 1.48, p=0.03 for KIR cen B/B versus KIR cen A/A) whereas in secondary AML it appeared to be advantageous (HR, 0.73, p=0.3 for KIR cen B/B versus KIR cen A/A). This evidence concerns the gene KIR3DL1 and myelodysplastic syndrome.