Itoh et al., suggested that differences in the elimination kinetics of PFAS between males and females, as previously shown for PFOA and PFOS in animal and in human studies may account for the different effects (80, 81), while other authors suggested that estrogen-induced increase in Thyroxine-binding globulin (TBG) production could alter measurements of circulating thyroid function parameters in newborn girls (82). This evidence concerns the gene SERPINA7 and thyroiditis.