Researchers have found that KM can inhibit NF-κB activation and mediate the expression of proinflammatory cytokines in RAW264.7, IPEC-J2 and hepatocellular carcinoma cells (Yuan et al., 2016b; Yuan et al., 2019a; Wu et al., 2020). Here, NFKB1 is linked to hepatocellular carcinoma.