Excessive and persistent activation of the NLRP3 inflammasome leads to loss of the control of IL-1β processing and contributes to several immune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, gout and colitis (Martinon et al., 2006; Yang et al., 2015; Guo et al., 2018; Mai et al., 2019). Here, NLRP3 is linked to rheumatoid arthritis.