In addition, Kong et al. demonstrated that Huanglian exerted antipyretic effect on yeast-induced pyrexia rats by regulating the expression of transient receptor potential vanilloid 1 (TRPV1, the activation of this protein will cause a burning sensation) and transient receptor potential melastatin 8 (TRPM8, a protein with the function of sensing cold). This evidence concerns the gene TRPM8 and Fever.