The researchers found that the human Aβ originated from APPsw/PS1dE9 transgenic AD mice could enter the brain of Wt mice by using a model of parabiosis between the transgenic AD mice and their wild-type littermates and caused Aβ deposition, over-phosphorylation of tau, cerebrovascular pathological changes and damage of LTP in hippocampal CA1 area in the Wt mice (Bu et al., 2017). Here, MAPT is linked to Alzheimer disease.