Fifty percent growth inhibition occurred at similar dose levels for MN1-driven AML and Kmt2a-Mllt3 driven murine AML, although it should be noted that in the Kmt2a-Mllt3 model, responses occurred earlier, and higher doses resulted in considerably more profound inhibition (Fig. 5B and Supplementary Fig. S4B, C). Here, KMT2A is linked to acute myeloid leukemia.