Gene Set Enrichment Analysis (GSEA) revealed downregulation of the MN1-driven leukemic gene expression program in Men1−/− versus Men1wt leukemias, a program previously defined by Heuser et al. [16] (Supplementary Table S1) as a group of genes that are upregulated in MN1-driven leukemic cells versus normal bone marrow (Fig. 4B). This evidence concerns the gene MN1 and leukemia.