Genomic profiling studies have identified the key pathways activated in the pathogenesis of mature B-cell neoplasms, such as B-cell receptor (BCR) signaling, NOTCH signaling, Toll-like receptor (TLR), phosphoinositide 3 kinase (PI3K)/AKT/mTOR signaling, and mitogen activated kinase (RAS/MAPK/ERK) pathways31. The gene discussed is MTOR; the disease is B-cell neoplasm.