We then investigated whether the MC4R p.Ile269Asn mutation was associated with T2D-related quantitative traits (BMI, BMI-SDS, WC, FPG, FPI, HOMA-IR, HOMA-B) in an independent sample of 994 children with NGT (Table 4, Supplementary Table 3). Here, MC4R is linked to type 2 diabetes mellitus.