NOS2 and obesity due to melanocortin 4 receptor deficiency: In contrast, as far as we know, several SNPs included our GRSs (i.e., AMPD1 rs2010899, NR3C1 rs4912905, CNTFR rs2183013, IGF1 rs1019731 as protector factors and NR3C1 rs13182800, CNTF rs2515362, NOS2A rs8068149, THRA rs7502966, ANGPTL4 rs1044250 and PTPN1 rs2143511 as risk factors) are new predictive factors, as they had not previously been associated with obesity or obesity related diseases nor had been significantly relevant in previous studies.