ACTR2 and breast carcinoma: Moreover, altered expressions of Arp2/3 complex and Wiskott-Aldrich syndrome protein family member 2 (WASP2) have been linked with poor prognosis of breast cancer, indicating a significant role of actin cytoskeleton dynamics in cancer progression72,73.Breast cancer is the most prevalent cancer types among women, and it becomes incurable once the disease has metastasized to the bones.