Indeed, mutations in the component of the core NF-κB signaling pathway have been implicated with relation to cancer24 and patients with Fanconi Anemia have a higher risk of cancer, particularly for acute myeloid leukemia and squamous cell carcinoma followed by ongoing work to study targeting of pathways that are synthetic lethal with loss of Fanconi Anemia pathway with Olaparib or other drugs25. Here, NFKB1 is linked to squamous cell carcinoma.