EFEMP1 and age-related macular degeneration: Increasing evidence suggests that F3 is involved in AMD including: (1) the accumulation of wild-type (WT) F3 surrounding drusen in AMD patient donor eyes20, but not around drusen of asymptomatic patients, (2) increased copy number variants near the EFEMP1 promoter (the gene that encodes for F3) were linked to increased risk for AMD21, and (3) a sequence variant, Asp49Ala (D49A), was discovered in a patient with cuticular drusen, a clinical subtype of AMD22.