Meanwhile, we investigate the associations between IgG N-glycan profiles and inflammation factors including anti-inflammatory (IL-4 and IL-10) and proinflammatory factors [IL-1β, IL-6, CRP, TNF-α, and interferon-gamma (IFN-γ)], which may further explain the role of IgG glycosylation in dementia. The gene discussed is TNF; the disease is dementia.