IFNG and cancer: We further checked the relationship between the IFN-γ/IMS ratio and TMB scores in TCGA data and found that there was a positive but weak association between them (r = 0.20, R2 = 0.042, p < 0.0001; Fig. 3B) on all samples from TCGA datasets (n = 11,043) and on selected cancer types (Supplementary Fig. 2).