TWIST2 and neoplasm: The identified IMS shows a strong presence of genes related to CAFs (FAP and PDGFRB22) and tumor-associated macrophages (TAMs) (CD16323 and SIGLEC124,25), as well as their associated cytokines or chemokines that lead to an immunosuppressive microenvironment (IL1026, CCL2, CCL8, and CCL1314) and stromal activities that lead to tumor proliferation, invasion and immune escape such as EMT or extracellular matrix (ECM) degradation (AXL27, TWIST2, ADAM1228, and COL6A329).