IFNG and squamous cell lung carcinoma: Importantly, tumors with high median IFN-γ/IMS values, most notably SKCM33, colon adenocarcinoma (COAD), CESC34, BLCA35, lung squamous cell carcinoma (LUSC)36 and liver hepatocellular carcinoma (LIHC), have shown clinical sensitivity to ICI therapies (Fig. 3G).