To figure out the potential role of SNHG1 in promoting prostate cancer progression, siRNA or lentivirus shRNA were used to knock down the endogenous expression of SNHG1 in DU145 and C4-2 cells and used an overexpression plasmid system to upregulate SNHG1 in DU145 and C4-2 cells (Fig. S1A). The gene discussed is SNHG1; the disease is Familial prostate cancer.