PRTG and gastric cancer: Furthermore, knockdown of PRTG expression (Fig. S3, B) significantly blocked the oncogenic effects of H. pylori on gastric cancer, which was reflected by decreased proliferation (Figs. 3C and S3C), increased apoptosis to chemotherapeutic drugs (Fig. 3D, E), G2/M or S phase arrests (Fig. S3, D, E) and pH2AX foci formation (Fig. S3, F), decreased migration, invasion and EMT progression (Fig. 3F, G) in PRTG silencing cells compared to non-targeting controls.