To assess whether mPS_colon is a prognostic indicator for CRC patients independent of various clinicopathologic features, we performed the multivariate analysis with the use of a Cox proportional hazard model including patient age and sex, disease stage, TP53 and KRAS mutation status, MMR status, and molecular subtypes proposed by the providers of the GSE39582 data set (Fig. 4a, Table 2). This evidence concerns the gene TP53 and colorectal carcinoma.