TNIP1 and colorectal carcinoma: To further investigate if ABIN-1 deficiency improves necroptosis-based cancer therapy, we established a xenograft model by injecting control shRNA CRC cells and Abin-1 shRNA CRC cells into the left flank and right flank of nude mice, respectively, to evaluate if Abin-1 deficiency could enhance necroptosis of tumor cells in vivo.