MCPH1 and Primary microcephaly: Of note there is a recently published paper reporting that two novel compound heterozygous missense variants (c.982 G > A and c.1273 T > A) in the exon 8 of MCPH1 gene caused primary microcephaly in a Saudi family; indicating an important role of middle regions of MCPH1 for brain development in addition to the N-terminal BRCT domain37.