CDCA8 and neoplasm: Subsequently, we further illustrated weaker fluorescence intensity (P < 0.05), slower tumor growth (P < 0.05), and lighter tumor weight (P < 0.05) in both shE2F1 and CDCA8 + shE2F1 groups in comparison with the respective control group (Figs. 6A, B and S6A-B), which was consistent with Ki67 expression in IHC (Fig. 6C).