RUVBL1 and central nervous system cancer: As Pontin and its close family member, Reptin is known to physically interact with multiple transcription factors with a strong involvement in carcinogenesis, and function as their co-activators to increase the corresponding transcription response8,16, we then tested whether Pontin cooperated with E2F1 to activate the transcription of the downstream targets of E2F1 in glioma.