Besides, the positive correlation between Pontin and six E2F1 targets (AURKA, CDK1, CDK4, CCNA2, CCNB2, E2F8) assessed by GEPIA in glioma further supported the positive regulation of E2F1 targets expressions by Pontin (Supplementary Fig. S3). The gene discussed is RUVBL1; the disease is central nervous system cancer.