As Pontin and its close family member, Reptin is known to physically interact with multiple transcription factors with a strong involvement in carcinogenesis, and function as their co-activators to increase the corresponding transcription response8,16, we then tested whether Pontin cooperated with E2F1 to activate the transcription of the downstream targets of E2F1 in glioma. The gene discussed is RUVBL2; the disease is glioma.