For example, HDAC4 inhibits HOXB13 transcription to affect cell growth in androgen receptor (AR)-negative prostate cancers15, but the HDAC4-RelB-p52 complex maintains a repressive chromatin state around the proapoptotic genes Bim and BMF and regulates multiple myeloma survival and growth16. This evidence concerns the gene HDAC4 and plasma cell myeloma.