Interestingly, we also found that NUPR1 depletion in MCF-7TamR cells resulted in decreased pro-migratory cytokine interleukin-6 (IL-6) production (Fig. S5c), suggesting a role for NUPR1 in the induction of IL-6 expression in Tam resistant breast cancer cells. Here, NUPR1 is linked to breast carcinoma.