The proliferation, migration, invasion, and VM formation ability of glioma cells in HNRNPD(−) + ZHX2(+)-NC group, HNRNPD(–)-NC + ZHX2(+) group, and HNRNPD(−) + ZHX2(+) group were significantly decreased, among which the HNRNPD(−) + ZHX2(+) group was the most significant (Fig. 2F–H). This evidence concerns the gene ZHX2 and central nervous system cancer.