Western blot was used to detect the changes of the expressions of VM-associated proteins in glioma cells, we found that the expression of MMP2, MMP9, and VE-cadherin were significantly reduced after overexpression of miR-651-3p and the anti-miR-651-3p group showed an oppisite effect (Fig. 4F). The gene discussed is CDH5; the disease is central nervous system cancer.