First, as P75CUX1 shared the same domain with P110CUX1 and P200CUX1, it was highly difficult just to target P75CUX1 and keep the other isoforms to understand how P75 isoform exactly functions; therefore, validation of mechanism of only the P75CUX1 in glioma warrants further investigation. Here, CUX1 is linked to central nervous system cancer.