Recently, studies have highlighted that P110 and P75, the shorter isoforms of CUX1, bind stably to DNA and function as important TFs to promote proliferation, migration, and invasion in various cancer types, including breast cancer23–26, prostate cancer26, lung cancer27,28, pancreatic cancer29,30 and pancreatic neuroendocrine neoplasms31. This evidence concerns the gene CUX1 and cancer.